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MARS therapy significantly reduces total plasma piperacillin levels by approximately one-third per session in critically ill liver failure patients, underscoring the need for therapeutic drug monitoring and individualized antibiotic dosing.
Ocular inflammation was linked to a higher risk of anti-adalimumab antibody formation in patients treated with adalimumab. More than 20% developed antibodies, supporting closer monitoring and therapeutic drug testing in high-risk patients.
This review synthesizes clinical evidence on busulfan pharmacokinetics, highlighting the critical role of TDM, the impact of body weight normalization, and significant drug interactions with deferasirox.