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Zetomipzomib Shows Promise in Difficult-to-Treat Autoimmune Hepatitis: Insights from the Phase 2a PORTOLA Study
Allergy & Immunologyautoimmune hepatitissteroid-sparing therapy

Zetomipzomib Shows Promise in Difficult-to-Treat Autoimmune Hepatitis: Insights from the Phase 2a PORTOLA Study

By MedXY|Sep 25, 2026

The PORTOLA phase 2a trial evaluates zetomipzomib, a selective immunoproteasome inhibitor, demonstrating numerically improved biochemical remission and steroid-sparing effects in autoimmune hepatitis patients with inadequate response to sta

Higher Oral Corticosteroid Exposure in Chronic Rhinosinusitis With Nasal Polyps Is Linked to More Systemic Harm
Internal Medicineadverse eventschronic rhinosinusitis with nasal polyps

Higher Oral Corticosteroid Exposure in Chronic Rhinosinusitis With Nasal Polyps Is Linked to More Systemic Harm

By MedXY|Jun 6, 2026

A nationwide Korean nested case-control study found that longer annual duration and higher cumulative oral corticosteroid dose in chronic rhinosinusitis with nasal polyps were associated with increased systemic adverse events, supporting st

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