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Etiologic investigations after status epilepticus (SE) demonstrate variable diagnostic yield and significantly influence treatment decisions, especially when guided by clinical pretest probability. Tailored diagnostic strategies enhance tim
This study found that cryptogenic NORSE causes severe, rapidly rising neuroaxonal injury, measured by NfL, and that higher NfL predicts worse short-term outcome. S100B was not useful for distinguishing groups.
A U.S. mortality analysis from 1999 to 2020 found increasing deaths from status epilepticus after 2007, with marked disparities by age, sex, race/ethnicity, and region.
In a multinational cross-sectional study, serum and CSF neurofilament light chain—unlike S100B—tracked severe acute brain injury in cryptogenic NORSE, rose rapidly over the first 3 weeks, and predicted poor short-term outcome, supporting ur