SRSF1

Unraveling the SRSF1-LCK Splicing Axis: A Novel Mechanism Underlying Regulatory T-Cell Impairment in Immune Thrombocytopenia

Reduced expression of splicing factor SRSF1 disrupts LCK exon 8 inclusion, impairing TCR signaling and regulatory T-cell induction, thereby contributing to immune dysregulation in immune thrombocytopenia.