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Decoding Cellular Interactions to Enhance Neoadjuvant PD-L1 Blockade Response in Esophageal Squamous Cell Carcinoma
newsimmunotherapyPD-L1 blockade

Decoding Cellular Interactions to Enhance Neoadjuvant PD-L1 Blockade Response in Esophageal Squamous Cell Carcinoma

By MedXY|Sep 22, 2026

This study reveals coordinated cellular programs underlying response and resistance to neoadjuvant PD-L1 blockade in ESCC, highlighting potential combinatorial immunotherapy targets for personalized treatment strategies.

GZMK+ CD8+ T Cells Drive Selective Acinar Cell Loss and Interferon Signaling in Sjögren’s Disease
newsCD8 T cellssingle-cell transcriptomics

GZMK+ CD8+ T Cells Drive Selective Acinar Cell Loss and Interferon Signaling in Sjögren’s Disease

By MedXY|Nov 4, 2025

Single-cell and spatial multi-omics reveal loss of a PRR4⁺CST3⁺ seromucous acinar population and accumulation of GZMK⁺CD8⁺ T cells that induce IFN-driven epithelial dysfunction in Sjögren’s disease.

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