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Exceptional and Durable Response to Selpercatinib in a Patient with Apparently RET-Negative, HRAS-, and NF1-Mutated Metastatic Medullary Thyroid Carcinoma
Diabetes & Endocrinologycase reportmedullary thyroid carcinoma

Exceptional and Durable Response to Selpercatinib in a Patient with Apparently RET-Negative, HRAS-, and NF1-Mutated Metastatic Medullary Thyroid Carcinoma

By MedXY|Oct 5, 2026

A 50-year-old woman with metastatic medullary thyroid carcinoma (MTC) lacking RET alterations exhibited a remarkable sustained response to selpercatinib, suggesting potential efficacy beyond RET-mutated cases.

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