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Breast Surgery in Metastatic Breast Cancer: Local Control Without Survival Benefit
General Surgerymetastatic breast cancerphẫu thuật vú

Breast Surgery in Metastatic Breast Cancer: Local Control Without Survival Benefit

By MedXY|Dec 16, 2025

Randomised trials show breast surgery improves local disease control but not overall survival in de novo metastatic breast cancer.

Atezolizumab–Bevacizumab Provides the Best Balance of Survival and Quality of Life in First‑Line Advanced Hepatocellular Carcinoma
newshepatocellular carcinomaimmunotherapy

Atezolizumab–Bevacizumab Provides the Best Balance of Survival and Quality of Life in First‑Line Advanced Hepatocellular Carcinoma

© 2026 MedXY
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By MedXY|Dec 14, 2025

A Bayesian network meta-analysis integrating health‑related quality of life and overall survival across first‑line trials in advanced hepatocellular carcinoma shows atezolizumab plus bevacizumab provides the most favorable combined patient‑

Five-Year Survival and Quality of Life After ECMO: Good Long-Term Outcomes but Persistent Functional Burden
Critical Carecritical careECMO

Five-Year Survival and Quality of Life After ECMO: Good Long-Term Outcomes but Persistent Functional Burden

By MedXY|Dec 11, 2025

A large prospective Dutch cohort reports 36% five-year survival after ECMO with generally satisfactory health-related quality of life (median EQ-5D 0.82) but ongoing problems with pain, mobility, activities, and work capacity.

Anatomic First or Invasive Angiography First? DISCHARGE Shows No QOL Advantage for CT over ICA in Stable Chest Pain
Cardiologyinvasive coronary angiographyquality of life

Anatomic First or Invasive Angiography First? DISCHARGE Shows No QOL Advantage for CT over ICA in Stable Chest Pain

By MedXY|Dec 3, 2025

In the DISCHARGE randomized trial prespecified secondary analysis, CT-first and ICA-first strategies produced similar long-term quality-of-life and angina outcomes in intermediate-risk stable chest pain patients over a median 3.5 years; imp

HNC-8D: A Head and Neck Cancer–Specific Utility Measure That Improves Discrimination of Post‑treatment Health States
newshead and neck cancerquality of life

HNC-8D: A Head and Neck Cancer–Specific Utility Measure That Improves Discrimination of Post‑treatment Health States

By MedXY|Nov 21, 2025

A multinational team developed and valued the HNC-8D, an 8-dimension, head and neck cancer–specific health utility instrument derived from EORTC QLQ-C30/H&N43. Valuation in 250 participants yielded mean absolute prediction errors of 0.0

[Lutetium-177]Lu-PSMA-617 Delays Quality-of-Life Decline, Pain Progression, and Symptomatic Skeletal Events in PSMA-Positive mCRPC: In-depth PSMAfore Analysis
news177Lu-PSMA-617mCRPC

[Lutetium-177]Lu-PSMA-617 Delays Quality-of-Life Decline, Pain Progression, and Symptomatic Skeletal Events in PSMA-Positive mCRPC: In-depth PSMAfore Analysis

By MedXY|Nov 5, 2025

PSMAfore shows that [177Lu]Lu-PSMA-617 given to taxane‑naive, PSMA-positive mCRPC patients delays worsening of health-related quality of life, pain, and first symptomatic skeletal events versus switching AR pathway inhibitors.

Long-Term Unmet Needs and Rehabilitation Gaps: Impacts on Stroke Survivors’ Quality of Life in Korea
Neurologyquality of liferehabilitation

Long-Term Unmet Needs and Rehabilitation Gaps: Impacts on Stroke Survivors’ Quality of Life in Korea

By MedXY|Oct 23, 2025

This study highlights how long-term unmet needs and rehabilitation deficits adversely affect the quality of life among stroke survivors in South Korea, emphasizing the need for community-based support systems.

Enhancing Quality of Life in Older Cancer Patients: The Impact of Comprehensive Geriatric Assessment and Patient Coaching
Internal Medicinequality of lifeSystemic Therapy

Enhancing Quality of Life in Older Cancer Patients: The Impact of Comprehensive Geriatric Assessment and Patient Coaching

By MedXY|Oct 20, 2025

The G-oncoCOACH trial demonstrates that comprehensive geriatric assessment combined with geriatric team implementation and extensive patient coaching significantly improves quality of life in older patients with solid tumors undergoing syst

Opioid Use in Rome IV Irritable Bowel Syndrome: Prevalence and Impact on Quality of Life and Healthcare in the UK
GastroenterologyHealthcare CostsIrritable Bowel Syndrome

Opioid Use in Rome IV Irritable Bowel Syndrome: Prevalence and Impact on Quality of Life and Healthcare in the UK

By MedXY|Oct 9, 2025

One in five UK patients with Rome IV IBS regularly use opioids, associated with worse quality of life, more psychological distress, and increased healthcare costs, highlighting a critical need for opioid stewardship in IBS management.

Gut Microbiota as a Key Determinant of Quality of Life Impairment in Inflammatory Bowel Disease
Gastroenterologygut microbiotainflammatory bowel disease

Gut Microbiota as a Key Determinant of Quality of Life Impairment in Inflammatory Bowel Disease

By MedXY|Oct 9, 2025

A recent cross-sectional study reveals that alterations in gut microbiota correlate more strongly with impaired health-related quality of life in IBD patients than clinical disease activity, suggesting novel microbial therapeutic targets be

Enhancing Quality of Life in KRASG12C-Mutated Chemorefractory Metastatic Colorectal Cancer: Insights from the CodeBreaK 300 Phase 3 Trial
newsKRASG12Cmetastatic colorectal cancer

Enhancing Quality of Life in KRASG12C-Mutated Chemorefractory Metastatic Colorectal Cancer: Insights from the CodeBreaK 300 Phase 3 Trial

By MedXY|Oct 9, 2025

The phase 3 CodeBreaK 300 trial shows sotorasib plus panitumumab improves health-related quality of life and clinical outcomes in KRASG12C-mutated metastatic colorectal cancer compared to standard care.

Maintaining Quality of Life While Extending Survival: HRQoL Outcomes from KEYNOTE-966 in Advanced Biliary Tract Cancer
Clinical UpdatesBiliary tract cancerpembrolizumab

Maintaining Quality of Life While Extending Survival: HRQoL Outcomes from KEYNOTE-966 in Advanced Biliary Tract Cancer

By MedXY|Oct 8, 2025

The KEYNOTE-966 trial demonstrates that adding pembrolizumab to gemcitabine and cisplatin improves overall survival in advanced biliary tract cancer patients without compromising health-related quality of life.

Enhancing Graves’ Disease Treatment: The Benefits of Adding L-Carnitine and Selenium to Methimazole Therapy
Diabetes & EndocrinologyL-Carnitinemethimazole

Enhancing Graves’ Disease Treatment: The Benefits of Adding L-Carnitine and Selenium to Methimazole Therapy

By MedXY|Oct 8, 2025

A recent randomized trial shows that supplementing methimazole with L-carnitine and selenium in Graves’ disease shortens disease duration, lowers antibody levels faster, reduces medication dose, and improves select symptoms, highlight

Dupilumab Enhances Quality of Life and Relieves Respiratory Symptoms in COPD Patients with Type 2 Inflammation: Insights from BOREAS and NOTUS Trials
Clinical UpdatesCOPDdupilumab

Dupilumab Enhances Quality of Life and Relieves Respiratory Symptoms in COPD Patients with Type 2 Inflammation: Insights from BOREAS and NOTUS Trials

By MedXY|Oct 8, 2025

Add-on dupilumab significantly improves health-related quality of life and respiratory symptoms in COPD patients with type 2 inflammation, according to pooled results from the BOREAS and NOTUS phase 3 trials.

Time-Restricted Eating in Overweight Adults: Effects on Sleep, Mood, and Quality of Life Remain Neutral
Clinical Updatesmoodobesity

Time-Restricted Eating in Overweight Adults: Effects on Sleep, Mood, and Quality of Life Remain Neutral

By MedXY|Oct 8, 2025

A randomized clinical trial found that different timing schedules of an 8-hour time-restricted eating window combined with Mediterranean diet education did not significantly affect sleep, mood, or quality of life in adults with overweight o

Enhancing Quality of Life in ERBB2-Positive Metastatic Breast Cancer: The PRO-DUCE Trial on Electronic Symptom and Vital Sign Monitoring During Trastuzumab Deruxtecan Therapy
OncologyERBB2-positive breast cancerpatient-reported outcomes

Enhancing Quality of Life in ERBB2-Positive Metastatic Breast Cancer: The PRO-DUCE Trial on Electronic Symptom and Vital Sign Monitoring During Trastuzumab Deruxtecan Therapy

By MedXY|Oct 7, 2025

The PRO-DUCE randomized trial demonstrates that electronic symptom and vital sign monitoring during trastuzumab deruxtecan therapy can preserve quality of life in ERBB2-positive metastatic breast cancer patients, with notable improvements i

Empowering Mental Health in Inflammatory Rheumatic Diseases Through Digital Interventions: Insights from a Pilot Randomized Clinical Trial
Clinical Updatesdigital psychological interventioninflammatory rheumatic diseases

Empowering Mental Health in Inflammatory Rheumatic Diseases Through Digital Interventions: Insights from a Pilot Randomized Clinical Trial

By MedXY|Oct 7, 2025

A pilot study demonstrates that a self-guided digital psychological intervention significantly reduces psychological distress and improves quality of life in patients with inflammatory rheumatic diseases, offering a scalable mental health s

Harnessing Digital Psychological Interventions to Improve Mental Health in Inflammatory Rheumatic Diseases: Insights from a Pilot Randomized Clinical Trial
Psychiatrydigital psychological interventioninflammatory rheumatic diseases

Harnessing Digital Psychological Interventions to Improve Mental Health in Inflammatory Rheumatic Diseases: Insights from a Pilot Randomized Clinical Trial

By MedXY|Oct 7, 2025

A pilot randomized clinical trial demonstrates that a self-guided digital psychological intervention effectively reduces psychological distress and improves quality of life among patients with inflammatory rheumatic diseases.

Multisite Randomized Trial of Inpatient Palliative Care in Hematopoietic Stem Cell Transplantation: Enhancing Patient and Caregiver Outcomes
Clinical Updateshematopoietic stem cell transplantationpalliative care

Multisite Randomized Trial of Inpatient Palliative Care in Hematopoietic Stem Cell Transplantation: Enhancing Patient and Caregiver Outcomes

By MedXY|Oct 7, 2025

Inpatient palliative care during hematopoietic stem cell transplantation improves patients’ quality of life, reduces depression and PTSD symptoms, and offers sustained psychological benefits up to six months post-transplant.

Impact of Screening and Care for Emotional and Cognitive Problems on Post-Ischemic Stroke Outcomes: Insights from a Dutch Multicenter Cluster-Randomized Trial
Neurologycognitive impairmentischemic stroke

Impact of Screening and Care for Emotional and Cognitive Problems on Post-Ischemic Stroke Outcomes: Insights from a Dutch Multicenter Cluster-Randomized Trial

By MedXY|Oct 6, 2025

A multicenter trial assessing emotional and cognitive screening post-ischemic stroke found no improvement in societal participation at 1 year, though modest early benefits in anxiety and quality of life were noted.

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