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This secondary analysis of the REPAIR study identifies prolonged active second stage labor, deep tears, and physician involvement in suturing as risk factors for perineal wound complications, while prophylactic antibiotics reduce this risk.
In a prospective cohort of 172 vulvar surgery patients, prophylactic antibiotics were not associated with fewer postoperative infections or complications, supporting the need for a randomized trial.
Cochrane review shows prophylactic antibiotics may reduce SSI risk in peripheral arterial reconstruction; closed incision negative pressure therapy offers possible benefit but evidence is low.
The REPAIR study demonstrates that prophylactic antibiotics reduce clinically relevant wound complications after episiotomy or second degree tears, highlighting a potential role for antibiotics in postpartum care.
Preoperative antibiotics in uncomplicated acute appendicitis do not reduce appendiceal perforation risk but lower surgical site infections. This large multicenter trial clarifies their limited role while awaiting timely appendectomy.
