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Automated Oxygen Control vs. Manual Care: Large-Scale Trial Finds No Difference in Clinical Outcomes for Extremely Preterm Infants

By MedXY|Feb 14, 2026

A multicenter randomized trial of 1,082 extremely preterm infants found that automated FiO2 control did not significantly reduce death or major morbidities compared to manual titration, though it remains a safe labor-saving tool for neonata

Cerebral Oximetry-Guided Treatment Significantly Stabilizes Oxygenation in Extremely Preterm Infants: Results from a Randomized Clinical Trial

Critical CareCerebral OximetryNeonatology

preterm infants

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Automated Oxygen Control vs. Manual Care: Large-Scale Trial Finds No Difference in Clinical Outcomes for Extremely Preterm Infants

Cerebral Oximetry-Guided Treatment Significantly Stabilizes Oxygenation in Extremely Preterm Infants: Results from a Randomized Clinical Trial

Pathophysiological Divergence in Preterm Infants: Early Lung Aeration and Gas Exchange as Predictors of Moderate-to-Severe Bronchopulmonary Dysplasia

Rethinking Oxygen Strategies for Preterm Infant Resuscitation: Evidence from TORPIDO, IPD-MA, and DCC Trials

Supplemental Donor Human Milk Did Not Speed Full Enteral Feeding in Moderate–Late Preterm Infants: Results From a Multisite Randomized Trial

Expectant Management Improves Early Survival Without Increasing BPD: Results from the PDA Randomized Clinical Trial

Hydrocortisone in Preterm Infants and School-Age Functional Outcomes: Comprehensive Review of Evidence from Randomized Clinical Trials

Personalized Prediction of Platelet Transfusion Outcomes in Preterm Infants with Severe Thrombocytopenia

Evaluating Early Intratracheal Budesonide to Reduce Bronchopulmonary Dysplasia in Extremely Preterm Infants: Insights from the BiB Randomized Clinical Trial

Enhanced Respiratory Support in Very Preterm Infants: Nasal Mask CPAP Outperforms Face Mask at Birth

Deferred Cord Clamping with High Oxygen in Extremely Preterm Infants: Enhancing Early Oxygenation Without Added Morbidity

Darbepoetin in Preterm Infants: Enhancing Red Cell Mass without Neurodevelopmental Benefit

Supplemental Donor Milk versus Infant Formula for Moderate to Late Preterm Infants: Implications from a Multisite Randomized Trial

Perinatal Antibiotic Exposure Alters Neonatal Gut Microbiota in Preterm Infants: Clinical Implications for Infection Risk and Microbial Maturation