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This study identifies baseline plasma metabolites, specifically 2hr plasma glucose and ceramide C18:0/C18:1 ratio, as predictors of persistent prediabetes vs. normoglycemia following lifestyle intervention over 5 years.
Metabolic status, reflected by glycemic trajectories, significantly modifies the skeletal response to active vitamin D analog eldecalcitol, with greater BMD improvements observed in individuals regressing from prediabetes to normoglycemia.
The effectiveness of lifestyle interventions promoting physical activity for diabetes risk reduction varies by prediabetes phenotype, with individuals having impaired fasting glucose showing the least response. Tailored approaches may enhan
This study reveals that Asian Indians with prediabetes or type 2 diabetes show significantly higher liver and abdominal fat despite similar BMI, highlighting liver fat’s key role in dysglycaemia and the importance of early interventio
Long-term exposure to particulate matter and lack of green space were associated with increased risk of prediabetes, especially impaired glucose tolerance phenotypes, and reduced remission of isolated impaired fasting glucose.
In a 30-week randomized trial, semaglutide improved insulin sensitivity, reduced insulin resistance, lowered fasting glucose, and produced substantial weight loss in patients with schizophrenia and prediabetes taking second-generation antip
Children born SGA receiving growth hormone showed insulin resistance and prediabetes rates similar to obesity, suggesting the need for careful glucose monitoring during and after treatment.
Adding the Area Deprivation Index to HbA1c improved prediction of type 2 diabetes within 1 year in youth with prediabetes, highlighting the importance of socioeconomic factors in diabetes risk.
The ELSA-Brasil study found that staging intermediate hyperglycaemia with fasting glucose plus 1-hour glucose better predicted type 2 diabetes than fasting glucose plus HbA1c, and a clinical risk score reduced unnecessary testing.
A multiethnic New Zealand **Synthesizing Article Draft** I’m now fully immersed in writing the article. I’m focusing on the “Introduction/Highlight,” integrating the essential findings regarding HbA1c, BMI, and Pacif
A post hoc analysis of the SPRINT trial reveals that the coexistence of prediabetes and subclinical myocardial injury or stress significantly escalates heart failure risk in hypertensive adults, suggesting a need for integrated glycemic and
A major long-term trial reveals that a moderate-protein, moderate-glycaemic index diet is more effective for sustaining prediabetes remission than high-protein alternatives, regardless of total weight loss.
A post hoc analysis of the three‑year SURMOUNT‑1 trial found that once‑weekly tirzepatide (5–15 mg) produced dose‑dependent reductions in 10‑year predicted risks for ASCVD, heart failure, total CVD and progression to type 2 diabetes versus
A 20-year multistate analysis of 328,049 adults with prediabetes in England shows age strongly shapes progression to type 2 diabetes, cancer, and death, with younger patients likely to remain in prediabetes—highlighting windows for tailored
The Pre-DICTED randomized trial found a stepped-care diabetes prevention program augmented with financial incentives reduced 3‑year diabetes conversion (34.8% vs 47.3%; adjusted RR 0.74), with metformin added for persistent high-risk partic
A post hoc analysis of PLIS and replication in the DPP show that achieving prediabetes remission—normalization of glucose—can prevent type 2 diabetes even without net weight loss, via improved insulin sensitivity, β‑cell function and favora
A groundbreaking study reveals that lifestyle changes improving fat distribution and insulin function can reverse prediabetes without weight loss, significantly cutting type 2 diabetes risk.
This review examines the first phase 3 randomized trial demonstrating that an AI-powered Diabetes Prevention Program lifestyle intervention is noninferior to human coaching in improving weight loss, HbA1c, and physical activity among adults
The HISTORI trial demonstrates that semaglutide significantly improves glycemic control, reduces weight, and enhances physical quality of life in schizophrenia patients treated with second-generation antipsychotics, without worsening psychi
A 16-week randomized trial demonstrates that daily hydroxytyrosol supplementation significantly reduces oxidative stress and inflammatory markers in overweight individuals with prediabetes, highlighting its potential in preventing aging-rel
