Tag
This large-scale case-control study examines how polygenic risk scores for suicide attempt intersect with clinical traits and environmental stressors. Findings indicate that genetic liability significantly correlates with aggression, depres
A secondary analysis of the LOOP study demonstrates that continuous ECG screening with implantable loop recorders significantly reduces stroke and systemic embolism in individuals with high genetic risk for atrial fibrillation, while potent
A landmark study reveals that former world-class rowers face a seven-fold higher risk of atrial fibrillation compared to the general population, driven by a combination of intensive cardiac remodeling and a strong polygenic predisposition.
A large-scale UK Biobank study demonstrates that combining NMR metabolomics, polygenic risk scores, and clinical biomarkers with SCORE2 significantly enhances cardiovascular risk prediction, potentially doubling the number of prevented even
A large-scale UK Biobank study demonstrates that combining NMR metabolomics and polygenic risk scores with the SCORE2 framework significantly improves cardiovascular risk discrimination, potentially doubling the number of preventable events
A comprehensive study of elite endurance athletes reveals that resting bradycardia (≤40 bpm) is common and driven by both fitness and a lower polygenic risk score for heart rate. These findings suggest that genetics may predispose individua
This study identifies key germline variants and demonstrates how combining genetic data with family history improves personalized prostate cancer risk assessment in men of African ancestry, guiding future screening strategies.
In pooled analyses of six TIMI trials (n=68,816), a validated PAD polygenic risk score was independently associated with prevalent PAD (OR per 1-SD 1.15) and incident major adverse limb events (HR per 1-SD 1.30), but added only modest impro
Partitioning a knee osteoarthritis polygenic score into BMI-associated and BMI-independent components clarifies genetic contributions, improves interpretability, and offers a path to tailored prediction and prevention.
A large-scale multi-ancestry genetic study confirms consistent associations between LDL cholesterol levels and coronary artery disease risk across six global ancestries, highlighting the generalizability of LDL-C lowering interventions beyo
Multi-ancestry polygenic risk scores significantly improve Alzheimer’s disease risk prediction in Hispanic populations compared to traditional single-ancestry models and APOE genotyping alone.
