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MedXY AI/MedXY News/Tag: polygenic risk score
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Integrating Metabolomics and Polygenics with SCORE2: A New Frontier in Cardiovascular Risk Stratification
Cardiologycardiovascular diseasemetabolomics

Integrating Metabolomics and Polygenics with SCORE2: A New Frontier in Cardiovascular Risk Stratification

By MedXY|Jan 5, 2026

A large-scale UK Biobank study demonstrates that combining NMR metabolomics, polygenic risk scores, and clinical biomarkers with SCORE2 significantly enhances cardiovascular risk prediction, potentially doubling the number of prevented even

Synergistic Integration of Metabolomics and Polygenic Scores Doubles the Impact of Cardiovascular Risk Prediction Models
Cardiologycardiovascular riskmetabolomics

Synergistic Integration of Metabolomics and Polygenic Scores Doubles the Impact of Cardiovascular Risk Prediction Models

By MedXY|Jan 5, 2026

A large-scale UK Biobank study demonstrates that combining NMR metabolomics and polygenic risk scores with the SCORE2 framework significantly improves cardiovascular risk discrimination, potentially doubling the number of preventable events

Beyond Vagal Tone: Genetic Predisposition and Physical Fitness Drive Profound Bradycardia in Elite Athletes
CardiologyBradycardiaCardiology

Beyond Vagal Tone: Genetic Predisposition and Physical Fitness Drive Profound Bradycardia in Elite Athletes

By MedXY|Dec 24, 2025

A comprehensive study of elite endurance athletes reveals that resting bradycardia (≤40 bpm) is common and driven by both fitness and a lower polygenic risk score for heart rate. These findings suggest that genetics may predispose individua

Refining Prostate Cancer Risk Prediction in Men of African Ancestry: Integrating Pathogenic Variants, Polygenic Scores, and Family History
newsAfrican ancestryfamily history

Refining Prostate Cancer Risk Prediction in Men of African Ancestry: Integrating Pathogenic Variants, Polygenic Scores, and Family History

By MedXY|Dec 17, 2025

This study identifies key germline variants and demonstrates how combining genetic data with family history improves personalized prostate cancer risk assessment in men of African ancestry, guiding future screening strategies.

Polygenic Risk Score Predicts Peripheral Artery Disease and Major Adverse Limb Events but Offers Modest Incremental Discrimination
Cardiologygeneticsmajor adverse limb events

Polygenic Risk Score Predicts Peripheral Artery Disease and Major Adverse Limb Events but Offers Modest Incremental Discrimination

By MedXY|Dec 2, 2025

In pooled analyses of six TIMI trials (n=68,816), a validated PAD polygenic risk score was independently associated with prevalent PAD (OR per 1-SD 1.15) and incident major adverse limb events (HR per 1-SD 1.30), but added only modest impro

Partitioning Knee Osteoarthritis Genetic Risk by BMI Association Clarifies Prediction and Mechanisms
newsBMIgenetics

Partitioning Knee Osteoarthritis Genetic Risk by BMI Association Clarifies Prediction and Mechanisms

By MedXY|Nov 2, 2025

Partitioning a knee osteoarthritis polygenic score into BMI-associated and BMI-independent components clarifies genetic contributions, improves interpretability, and offers a path to tailored prediction and prevention.

Genetic Insights into LDL Cholesterol and Coronary Artery Disease Risk Across Diverse Global Populations
Cardiologycoronary artery diseasegenetics

Genetic Insights into LDL Cholesterol and Coronary Artery Disease Risk Across Diverse Global Populations

By MedXY|Oct 30, 2025

A large-scale multi-ancestry genetic study confirms consistent associations between LDL cholesterol levels and coronary artery disease risk across six global ancestries, highlighting the generalizability of LDL-C lowering interventions beyo

Advancing Alzheimer’s Risk Prediction: Multi-Ancestry Polygenic Risk Scores in Hispanic Populations
Clinical UpdatesAlzheimer's diseaseHispanic population

Advancing Alzheimer’s Risk Prediction: Multi-Ancestry Polygenic Risk Scores in Hispanic Populations

By MedXY|Oct 1, 2025

Multi-ancestry polygenic risk scores significantly improve Alzheimer’s disease risk prediction in Hispanic populations compared to traditional single-ancestry models and APOE genotyping alone.

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