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This article reviews a large retrospective study revealing significant associations between CYP2D6 and CYP2C19 genotypes and venlafaxine treatment failure, highlighting the potential for genotype-guided personalized antidepressant therapy.
The gain-of-function GLP1R R131Q variant slows β-cell decline and improves glycemic response to GLP-1 receptor agonists, highlighting its potential role in precision diabetes therapeutics.
Researchers have identified a genetic variant in the cubilin gene (CUBN, rs1801222) that significantly increases the risk of metformin-induced vitamin B12 deficiency, with carriers of the AA genotype experiencing deficiency up to twice as f
A multicentre cohort study confirms that upfront 30% irinotecan dose reductions for UGT1A1 poor metabolisers effectively prevent severe toxicity without compromising progression-free or overall survival in colorectal and pancreatic cancer p
The IL23R1142G>A genetic variant strongly predicts paradoxical psoriasis in inflammatory bowel disease patients undergoing anti-TNFα therapy, guiding personalized treatment decisions.
