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ACP 2026 Position Paper: A Policy Roadmap to Make Obesity Prevention and Treatment Affordable, Accessible, and Stigma-Free
Internal Medicineobesity treatmentobesity

ACP 2026 Position Paper: A Policy Roadmap to Make Obesity Prevention and Treatment Affordable, Accessible, and Stigma-Free

By MedXY|Aug 7, 2026

The American College of Physicians’ 2026 position paper calls for comprehensive payer coverage, healthy food access, bias reduction, and research to tackle adult obesity through multisector public policy.

Biliopancreatic Diversion for Severe Obesity: Landmark 50-Year Study Reveals Lifelong Benefits and Risks
Diabetes & Endocrinologybariatric surgery
long-term outcomes

Biliopancreatic Diversion for Severe Obesity: Landmark 50-Year Study Reveals Lifelong Benefits and Risks

By MedXY|May 11, 2026

A 50-year follow-up of biliopancreatic diversion shows sustained weight loss and diabetes remission, but alarmingly high nutritional complications decades after surgery.

Efficacy and Safety of Cagrilintide-Semaglutide Combination vs Semaglutide Alone for Weight Management in East Asian Adults with Overweight/Obesity: REDEFINE 5 Trial
Diabetes & Endocrinologyamylin analogueGLP-1/胰高血糖素激动剂

Efficacy and Safety of Cagrilintide-Semaglutide Combination vs Semaglutide Alone for Weight Management in East Asian Adults with Overweight/Obesity: REDEFINE 5 Trial

By MedXY|Apr 22, 2026

Phase 3a trial in Japan/Taiwan shows cagrilintide-semaglutide combination delivers superior weight loss (18.4%) versus semaglutide alone (11.9%) in adults with overweight/obesity ± type 2 diabetes, with comparable safety profiles dominated

Signaling-Biased Dual GLP-1/GIP Agonist CT-388 Achieves Remarkable 8% Weight Loss in Just Four Weeks
Diabetes & Endocrinologyobesity treatment

Signaling-Biased Dual GLP-1/GIP Agonist CT-388 Achieves Remarkable 8% Weight Loss in Just Four Weeks

By MedXY|Feb 4, 2026

A Phase 1 study of CT-388, a novel signaling-biased dual GLP-1/GIP receptor agonist, demonstrated up to 8% body weight reduction in 28 days with a safety profile consistent with existing incretin therapies, signaling a potential shift in me

Patterns and Predictors of GLP-1 Agonist Use After Bariatric Surgery in US Adults
Diabetes & Endocrinologybariatric surgeryGLP-1 receptor agonists

Patterns and Predictors of GLP-1 Agonist Use After Bariatric Surgery in US Adults

By MedXY|Oct 10, 2025

A large US cohort study reveals that 14% of bariatric surgery patients start GLP-1 receptor agonists postoperatively, with higher use seen among women, sleeve gastrectomy recipients, and those with greater BMI regain.

Orforglipron: A Promising Oral GLP-1 Receptor Agonist for Long-Term Obesity Management
Diabetes & Endocrinologyclinical trialGLP-1 receptor agonist

Orforglipron: A Promising Oral GLP-1 Receptor Agonist for Long-Term Obesity Management

By MedXY|Oct 9, 2025

Orforglipron, a novel oral GLP-1 receptor agonist, demonstrated significant and sustained weight reduction in obese adults without diabetes in a 72-week phase 3 trial, with a tolerable safety profile consistent with existing GLP-1 therapies

SANA: A Novel Nitroalkene Salicylate Derivative Promoting Creatine-Dependent Thermogenesis and Weight Loss
Clinical Updatesmetabolic healthobesity treatment

SANA: A Novel Nitroalkene Salicylate Derivative Promoting Creatine-Dependent Thermogenesis and Weight Loss

By MedXY|Sep 17, 2025

SANA, a nitroalkene derivative of salicylate, enhances creatine-dependent thermogenesis to reduce obesity and improve metabolic health, showing promising safety and efficacy in preclinical and early clinical studies.

Amycretin: A Promising First-in-Class Dual GLP-1 and Amylin Receptor Agonist for Overweight and Obesity
Clinical UpdatesamycretinGLP-1 receptor agonist

Amycretin: A Promising First-in-Class Dual GLP-1 and Amylin Receptor Agonist for Overweight and Obesity

By MedXY|Oct 8, 2025

Amycretin, a novel dual GLP-1 and amylin receptor agonist, demonstrated safety, tolerability, and dose-proportional pharmacokinetics in adults with overweight or obesity, supporting further trials on its weight loss efficacy.

Advancing Obesity Management: Once-Monthly Maridebart Cafraglutide Demonstrates Significant Weight Loss Efficacy
Clinical UpdatesGLP-1 receptor agonistobesity treatment

Advancing Obesity Management: Once-Monthly Maridebart Cafraglutide Demonstrates Significant Weight Loss Efficacy

By MedXY|Oct 6, 2025

Maridebart cafraglutide, a novel once-monthly peptide-antibody conjugate, significantly reduces body weight in individuals with obesity, with and without type 2 diabetes, offering a new therapeutic option based on phase 2 trial results.

Five Oral Obesity Drugs That Could Rival Eli Lilly’s Orforglipron in the Weight Loss Arena
Clinical Updatesobesity treatmentorforglipron

Five Oral Obesity Drugs That Could Rival Eli Lilly’s Orforglipron in the Weight Loss Arena

By MedXY|Oct 3, 2025

Eli Lilly’s oral GLP-1 drug orforglipron marks a milestone in obesity treatment, yet competition from novel oral therapies by Novo Nordisk, Viking Therapeutics, Roche, Terns Pharmaceuticals, and Rhythm Pharmaceuticals is intensifying,

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