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Preserved Thalamic Bioenergetics and Neuronal Function in Painful Diabetic Peripheral Neuropathy: Insights from Dual Magnetic Resonance Spectroscopy
Diabetes & Endocrinologyneuropathic painDiabetic peripheral neuropathy

Preserved Thalamic Bioenergetics and Neuronal Function in Painful Diabetic Peripheral Neuropathy: Insights from Dual Magnetic Resonance Spectroscopy

By MedXY|Sep 15, 2026

A study using dual magnetic resonance spectroscopy reveals contrasting thalamic neuronal and bioenergetic profiles in painful versus painless diabetic peripheral neuropathy, highlighting potential biomarkers and mechanisms underlying neurop

A Pain-Predominant Dry Eye Phenotype Emerges: Severe Symptoms, Few Ocular Signs, and Strong Links to Migraine and Psychiatric Disease
© 2026 MedXY
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Neurology
dry eye disease
Migraine

A Pain-Predominant Dry Eye Phenotype Emerges: Severe Symptoms, Few Ocular Signs, and Strong Links to Migraine and Psychiatric Disease

By MedXY|Jun 1, 2026

A 2026 Ophthalmology report identified a pain-predominant dry eye phenotype in 6.9% of patients, marked by high symptom burden, minimal surface signs, and enrichment for migraine and psychiatric comorbidity.

Effect of Electroacupuncture on Postherpetic Neuralgia: A Randomized Clinical Trial
Neurologyelectroacupunctureneuropathic pain

Effect of Electroacupuncture on Postherpetic Neuralgia: A Randomized Clinical Trial

By MedXY|May 28, 2026

A randomized clinical trial found that electroacupuncture reduced pain more than sham treatment in postherpetic neuralgia, with benefits lasting at least one month and no major safety concerns.

The Hidden Driver of Chronic Pain: How Macrophages Fuel Neuropathic Symptoms
Anesthesiologychronic painiPSC

The Hidden Driver of Chronic Pain: How Macrophages Fuel Neuropathic Symptoms

By MedXY|Mar 27, 2026

Researchers using human stem cell models have discovered that macrophages actively amplify the electrical signals of damaged nerves, driving the spontaneous pain characteristic of neuropathy, offering a new target for non-opioid pain relief

Neuro-Immune Crosstalk: Macrophages Directly Amplify Spontaneous Activity in Damaged Human Sensory Neurons
AnesthesiologyiPSCMacrophages

Neuro-Immune Crosstalk: Macrophages Directly Amplify Spontaneous Activity in Damaged Human Sensory Neurons

By MedXY|Mar 22, 2026

A groundbreaking human iPSC-derived co-culture study reveals that macrophages respond to neuronal injury by adopting a pro-algesic state, directly intensifying spontaneous neuronal firing—a key driver of chronic neuropathic pain and a novel

Pregabalin Restores Sleep and Circadian Rhythms in Neuropathic Pain—Unlike Morphine: Translational Insights from a Mouse SNI Model
Anesthesiologycircadian rhythmsneuropathic pain

Pregabalin Restores Sleep and Circadian Rhythms in Neuropathic Pain—Unlike Morphine: Translational Insights from a Mouse SNI Model

By MedXY|Nov 5, 2025

In a mouse spared nerve injury model, pregabalin—but not morphine—restored REM sleep, normalized locomotor and temperature circadian rhythms, and reversed spinal circadian gene changes. Findings suggest analgesic choice can differentially a

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