Cardiology
Metabolic Splicing Nexus: HNRNPK Lactylation Drives Inflammation and Injury in Myocardial Ischemia/Reperfusion
Lactylation of HNRNPK at K405 links metabolic stress to inflammatory RNA splicing, promoting pathological Jag2 isoform expression and exacerbating myocardial ischemia/reperfusion injury, revealing novel therapeutic targets.
