Diabetes & EndocrinologyGLP-1 receptor agonistmajor depressive disorder
Semaglutide Reduced Effort Discounting and Improved Motivation Signals in Major Depressive Disorder
By MedXY|May 5, 2026
In a 16-week randomized trial, adjunctive oral semaglutide improved effort-based decision-making in adults with major depressive disorder and overweight or obesity, suggesting a potential role for GLP-1 receptor agonism in reward-related dy
