MLH3

Germline MSH3 and MLH3 Mutations as Tumor Suppressors Elevating Colorectal Cancer Risk via Hypermutation Signature ID4

Heterozygous germline mutations in MSH3 and likely MLH3 confer an increased colorectal cancer risk through somatic second hits, inducing hypermutant, microsatellite-stable tumors characterized by signature ID4 and excess somatic deletions.