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A systematic review and meta-analysis of RCTs indicates Pilates may improve pain and function in knee osteoarthritis patients, though evidence quality is low and safety data insufficient. Caution is warranted in interpreting results, highli
This comprehensive meta-analysis quantifies the efficacy of five major antihypertensive drug classes and their combinations, providing clinicians with evidence-based guidance on blood pressure-lowering intensity to optimize hypertension tre
This meta-analysis confirms that cognitive behavioral therapy for insomnia (CBT-I) is an effective, well-accepted treatment improving sleep outcomes across diverse chronic diseases, with minimal adverse effects and potential for broad clini
A meta-analysis found a population-level association between increased per capita alcohol consumption and higher suicide mortality, without sex differences, suggesting alcohol reduction as a vital component in suicide prevention.
A large meta-analysis in The Lancet demonstrates that clopidogrel reduces MACCE risk by 14% over aspirin in CAD secondary prevention, with comparable safety over 5.5 years.
A patient‑level meta‑analysis of randomized trials finds transcatheter aortic valve implantation (TAVI) reduces 1‑year risk of death or stroke versus surgical AVR in low– to intermediate‑risk patients—informing patient selection, heart‑team
This review synthesizes recent clinical evidence on transcranial magnetic stimulation across neurological and psychiatric disorders, highlighting efficacy, optimization challenges, and future research directions.
A comprehensive meta-analysis confirms that Helicobacter pylori eradication reduces gastric cancer risk and related deaths, especially benefiting high-risk groups, supporting widespread screening and treatment.
A new meta-analysis finds that the average time from dementia symptom onset to diagnosis is 3.5 years, with even longer delays in younger patients and those with frontotemporal dementia.
