Gastroenterology12-HETECD8+ T cell dysfunction
Metabolic Checkpoint Role of PCK1 Deficiency in Promoting MASH-HCC via 12-HETE-Induced CD8+ T Cell Dysfunction
By MedXY|Aug 22, 2026
PCK1 deficiency in hepatocytes drives metabolic reprogramming that fosters MASH-HCC progression by inducing CD8+ T cell dysfunction through 12-HETE-p38 signaling, highlighting a metabolic immunotherapy target to enhance anti-PD-1 efficacy.