CardiologyFBN1 MutationMarfan Syndrome
Beyond the Aorta: Genetic Stratification Redefines Mitral Valve Risk in Marfan Syndrome
By MedXY|Mar 11, 2026
A breakthrough study reveals that specific FBN1 genotypes, particularly in-frame variants in the DNCD region, significantly elevate the risk of early mitral valve surgery in Marfan syndrome patients, paving the way for genotype-guided clini