Cardiologycongenital heart diseaseMAML1
Disrupted MAML1 Phase Separation Emerges as a New Mechanism Linking Notch Failure to Congenital Heart Disease
By MedXY|Jun 5, 2026
A Circulation study identifies MAML1 as a candidate congenital heart disease gene and shows that defective phase separation in endocardial cells suppresses Notch signaling, impairing endocardial-to-mesenchymal transition and causing septal