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Unraveling Abdominal Aortic Aneurysm: Epigenetic Links to Inflammation and Lipid Metabolism
CardiologyAbdominal Aortic AneurysmChuyển hóa mỡ máu

Unraveling Abdominal Aortic Aneurysm: Epigenetic Links to Inflammation and Lipid Metabolism

By MedXY|Oct 3, 2026

An epigenome-wide study reveals that DNA methylation markers linked to inflammatory pathways and blood lipid traits play a causal role in abdominal aortic aneurysm development, offering potential for improved risk prediction and therapeutic

Genetically Mediated LDL Cholesterol Variations and Their Limited Impact on Venous Thromboembolism Risk
CardiologygeneticsLDL Cholesterol
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Genetically Mediated LDL Cholesterol Variations and Their Limited Impact on Venous Thromboembolism Risk

By MedXY|Sep 25, 2026

This study reveals that lifelong genetic differences in LDL cholesterol levels do not significantly affect the risk of venous thromboembolism (VTE), suggesting LDL-C may not be a major causal factor in VTE development.

Unexpected Early Postoperative Lipid Deterioration in Cushing’s Syndrome: Implications for Cardiovascular Risk and Management
Cardiologycardiovascular riskCushing's Syndrome

Unexpected Early Postoperative Lipid Deterioration in Cushing’s Syndrome: Implications for Cardiovascular Risk and Management

By MedXY|Sep 22, 2026

This study reveals that lipid profiles paradoxically worsen during the early remission phase after curative surgery for Cushing’s syndrome, highlighting a critical window for cardiovascular risk and targeted intervention.

Targeting ACKR3/CXCR7 Enhances Platelet Anticoagulant Lipids and Modulates Procoagulant Function: Implications for Thrombosis Management
CardiologyACKR3acylcarnitines

Targeting ACKR3/CXCR7 Enhances Platelet Anticoagulant Lipids and Modulates Procoagulant Function: Implications for Thrombosis Management

By MedXY|Sep 17, 2026

Pharmacological activation of CXCR7 regulates platelet lipid metabolism, preserves mitochondrial function, and reduces procoagulant activity, offering a novel therapeutic strategy to mitigate thrombotic risk in cardiovascular diseases.

Advancing Familial Hypercholesterolemia Diagnosis: Activity-Normalized Prime Editing for Comprehensive LDLR Variant Classification
CardiologyChuyển hóa mỡ máuGenetic variant classification

Advancing Familial Hypercholesterolemia Diagnosis: Activity-Normalized Prime Editing for Comprehensive LDLR Variant Classification

By MedXY|Sep 6, 2026

A novel prime editing screening method enables precise functional classification of LDLR gene variants, enhancing diagnosis and therapeutic strategies for familial hypercholesterolemia.

Dietary Lipid Sequestration and Metabolic Rewiring in Colorectal Cancer: New Mechanistic Frontiers and Therapeutic Potential
Clinical UpdatesAxit arachidonicChuyển hóa mỡ máu

Dietary Lipid Sequestration and Metabolic Rewiring in Colorectal Cancer: New Mechanistic Frontiers and Therapeutic Potential

By MedXY|Mar 22, 2026

This review synthesizes recent evidence on how colorectal cancer tissues directly absorb extrinsic long-chain fatty acids from the intestinal lumen, particularly in right-sided tumors, and explores the critical interplay between lipid metab

Berberine Improves Lipid Profiles and Inflammation but Fails to Reduce Visceral and Liver Fat in MASLD
Diabetes & EndocrinologyBerberineChuyển hóa mỡ máu

Berberine Improves Lipid Profiles and Inflammation but Fails to Reduce Visceral and Liver Fat in MASLD

By MedXY|Jan 24, 2026

The BRAVO randomized clinical trial demonstrates that while 1 g/d of berberine significantly lowers LDL-C and hs-CRP in individuals with obesity and MASLD, it does not impact visceral adipose tissue area or liver fat content over a six-mont

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