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This study demonstrates that insulin resistance indices, particularly TyG-WC, TyG-WHtR, and METS-IR, robustly predict the risk and progression of cardio-renal-metabolic multimorbidity, with inflammation and kidney function mediating these a
Lanifibranor, a pan-PPAR agonist, significantly reduces liver fat and improves insulin sensitivity at multiple tissue sites in type 2 diabetes patients with MASLD, offering a new therapeutic avenue to address underlying metabolic dysfunctio
This study reveals that excess adiposity, rather than insulin resistance or diabetes, predominantly drives left heart abnormalities and elevated pulmonary pressures in HFpEF, highlighting the need for targeted cardiometabolic therapies beyo
A retrospective study shows high and fluctuating triglyceride-glucose (TyG) index trajectories predict increased short- and long-term mortality in ICU patients with atrial fibrillation, highlighting TyG dynamics as a valuable prognostic bio
This study reveals that fluctuating high triglyceride-glucose (TyG) index trajectories in critically ill atrial fibrillation patients significantly predict increased all-cause mortality up to one year post-ICU admission, offering a novel pr
Dynamic C-peptide patterns during OGTT uncover metabolic heterogeneity in GDM, identifying insulin-resistant women at risk for fetal overgrowth and normoglycemic women at risk for preeclampsia, suggesting improved stratified treatment beyon
This study reveals that increased serum free thyroxine and insulin resistance-associated factors are linked to higher malignancy risk in thyroid nodules, suggesting a complex interplay between metabolic and hormonal factors in thyroid cance
This clinical trial compared two modified intermittent fasting strategies to continuous energy restriction for weight loss and insulin resistance improvements in night shift workers, finding no significant differences but overall health ben
New GRADE sub-study reveals that somatic symptoms of depression, not cognitive-affective symptoms, are chiefly associated with inflammation and insulin resistance in type 2 diabetes, highlighting a pathophysiological bridge for targeted int