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Fungal Endophthalmitis Associated with Contaminated Trypan Blue in Cataract Surgery: A Retrospective Case Series

Fungal Endophthalmitis Associated with Contaminated Trypan Blue in Cataract Surgery: A Retrospective Case Series

Six cases of postoperative fungal endophthalmitis caused by Sarocladium kiliense following cataract surgery involving contaminated trypan blue are reported, highlighting diagnosis, management, and outcomes.

Section: Infectious DiseasesJul 24, 2026

Hantavirus in Pregnancy: Why Obstetricians Need a High Index of Suspicion

Hantavirus in Pregnancy: Why Obstetricians Need a High Index of Suspicion

Hantavirus infection in pregnancy is rare but potentially fatal. Obstetricians should suspect it after rodent or travel exposure, recognize rapid respiratory decline, and prioritize supportive critical care because no proven antiviral thera

Section: Infectious DiseasesJun 20, 2026

Culture-Negative Infective Endocarditis in the Modern Diagnostic Era: Patient Characteristics and Heterogeneity in a Nationwide Cohort

Culture-Negative Infective Endocarditis in the Modern Diagnostic Era: Patient Characteristics and Heterogeneity in a Nationwide Cohort

A nationwide Danish study found that culture-negative infective endocarditis was less common than previously reported, often presented without fever or sepsis, and showed higher embolic risk. PET-CT was especially useful in prosthetic valve

Section: CardiologyJun 11, 2026

Impact of Appropriate Antimicrobial Therapy on ICU Patient Outcomes: Subanalysis of the DIANA Study Dataset

Impact of Appropriate Antimicrobial Therapy on ICU Patient Outcomes: Subanalysis of the DIANA Study Dataset

In critically ill ICU patients with confirmed bacterial infections, appropriate empiric antimicrobial therapy was common and independently linked to lower 28-day mortality and more antimicrobial-free days.

Section: Critical CareJun 5, 2026

Hidden Triggers: Recent Infections Linked to a 2.6-Fold Increase in Cryptogenic Stroke Risk in Young Adults

Hidden Triggers: Recent Infections Linked to a 2.6-Fold Increase in Cryptogenic Stroke Risk in Young Adults

The SECRETO study reveals that infections within the preceding week significantly increase the risk of cryptogenic ischemic stroke in patients aged 18–49, with elevated von Willebrand Factor and Factor VIII levels serving as critical biomar

Section: Infectious DiseasesMar 30, 2026

Distinct Biological Pathways Drive Restrictive and Obstructive Post-Tuberculosis Lung Disease: Insights from a Kenyan Cohort

Distinct Biological Pathways Drive Restrictive and Obstructive Post-Tuberculosis Lung Disease: Insights from a Kenyan Cohort

A prospective Kenyan cohort study identifies that post-tuberculosis lung disease (PTLD) affects 50% of survivors, driven by divergent transcriptomic signatures: early pro-fibrotic inflammation in restrictive phenotypes and persistent interf

Section: Infectious DiseasesMar 25, 2026

Recent Infections Act as a Transient Trigger for Cryptogenic Stroke in Young Adults via Thromboinflammatory Pathways

Recent Infections Act as a Transient Trigger for Cryptogenic Stroke in Young Adults via Thromboinflammatory Pathways

The SECRETO study demonstrates that infections within the preceding week increase the odds of cryptogenic ischemic stroke by 2.6-fold in young adults, primarily driven by transient increases in von Willebrand Factor and Factor VIII levels.

Section: Infectious DiseasesMar 18, 2026

Obesity Linked to Three-Fold Increase in Severe Infection Risk: A Global Analysis of 925 Pathogens

Obesity Linked to Three-Fold Increase in Severe Infection Risk: A Global Analysis of 925 Pathogens

A large-scale multicohort study reveals that adult obesity significantly increases the risk of hospitalization and death across nearly 1,000 infectious diseases, accounting for approximately one in ten infection-related deaths globally.

Section: Infectious DiseasesFeb 16, 2026

2024-2025 COVID-19 Vaccines Provide 79% Protection Against Critical Illness Despite Viral Evolution

2024-2025 COVID-19 Vaccines Provide 79% Protection Against Critical Illness Despite Viral Evolution

A multicenter study reveals that 2024-2025 COVID-19 vaccines offer 40% protection against hospitalization and 79% against critical illness or death, maintaining efficacy against emerging JN.1 descendants like KP.3.1.1 and XEC.

Section: Infectious DiseasesFeb 6, 2026

RSV-Related Hospitalization Linked to Surge in Acute Myocardial Infarction and Stroke Risk

RSV-Related Hospitalization Linked to Surge in Acute Myocardial Infarction and Stroke Risk

A large-scale study reveals that RSV hospitalization significantly increases the risk of myocardial infarction, stroke, and heart failure exacerbations, with the highest risk occurring within the first week post-admission, emphasizing the c

Section: CardiologyFeb 6, 2026

AI-Driven Decision Support for Antibiotic Switching: Why Clinicians Value Caution Over Speed

AI-Driven Decision Support for Antibiotic Switching: Why Clinicians Value Caution Over Speed

A randomized multimethod study reveals that while AI clinical decision support systems for antibiotic switching are well-received, their primary influence is reinforcing conservative prescribing. The study underscores that usability and cli

Section: AIJan 16, 2026

Two-Dose HeV-sG-V Regimen Demonstrates Robust Neutralizing Antibody Response Against Nipah Virus in Phase 1 Trial

Two-Dose HeV-sG-V Regimen Demonstrates Robust Neutralizing Antibody Response Against Nipah Virus in Phase 1 Trial

A Phase 1 trial confirms that the HeV-sG-V vaccine is safe and, when administered in a two-dose 100 μg regimen, induces high levels of neutralizing antibodies against both Bangladesh and Malaysia strains of the Nipah virus.

Section: Infectious DiseasesJan 14, 2026

Delpazolid Emerges as a Safer Oxazolidinone Alternative for Tuberculosis: Results from the PanACEA-DECODE-01 Trial

Delpazolid Emerges as a Safer Oxazolidinone Alternative for Tuberculosis: Results from the PanACEA-DECODE-01 Trial

The Phase 2b PanACEA-DECODE-01 trial identifies delpazolid 1200 mg once daily as an effective and safer oxazolidinone alternative to linezolid, demonstrating a 38% faster mycobacterial load decline when added to a bedaquiline, delamanid, an

Section: Infectious DiseasesJan 13, 2026

Omadacycline Establishes Noninferiority to Moxifloxacin in Community-Acquired Bacterial Pneumonia: The OPTIC-2 Phase 3b Trial Results

Omadacycline Establishes Noninferiority to Moxifloxacin in Community-Acquired Bacterial Pneumonia: The OPTIC-2 Phase 3b Trial Results

The OPTIC-2 phase 3b trial confirms that omadacycline is noninferior to moxifloxacin for treating community-acquired bacterial pneumonia (CABP). This once-daily aminomethylcycline offers a robust IV-to-oral monotherapy option with a favorab

Section: Infectious DiseasesDec 30, 2025

Nirsevimab Outperforms Maternal Vaccination in Reducing Severe RSV Outcomes: Insights from Comparative Real-World Evidence

Nirsevimab Outperforms Maternal Vaccination in Reducing Severe RSV Outcomes: Insights from Comparative Real-World Evidence

Recent real-world data from the US and France indicate that while both maternal RSV vaccination and nirsevimab are effective, nirsevimab may offer superior protection against hospitalization and intensive care admission for infants in their

Section: Infectious DiseasesDec 24, 2025

High-Dose Oral Rifampin Did Not Improve Survival in Tuberculous Meningitis—HARVEST Trial Shows No Benefit and Possible Harm

High-Dose Oral Rifampin Did Not Improve Survival in Tuberculous Meningitis—HARVEST Trial Shows No Benefit and Possible Harm

A multinational randomized trial found that adding high‑dose oral rifampin (total 35 mg/kg for 8 weeks) to standard therapy did not reduce 6‑month mortality in adults with tuberculous meningitis and was associated with more drug‑induced liv

Section: Infectious DiseasesDec 19, 2025

Shorter Is Safe: Adjusted Analyses of BALANCE Confirm Non‑Inferiority of 7‑Day Antibiotic Courses for Uncomplicated Bloodstream Infection

Shorter Is Safe: Adjusted Analyses of BALANCE Confirm Non‑Inferiority of 7‑Day Antibiotic Courses for Uncomplicated Bloodstream Infection

A post-hoc analysis of the BALANCE randomized trial shows that after accounting for treatment non-adherence using causal inference methods, 7 days of antibiotics for uncomplicated non‑Staphylococcus aureus bloodstream infection remains non‑

Section: Infectious DiseasesNov 24, 2025

Emergence of a Novel Mammarenavirus Closely Related to Lassa Virus in a Patient with Meningoencephalitis in Chad

Emergence of a Novel Mammarenavirus Closely Related to Lassa Virus in a Patient with Meningoencephalitis in Chad

A 37-year-old man developed meningoencephalitis caused by a novel mammarenavirus genetically related to Lassa virus after travel to Chad, highlighting emergence of a new pathogen with distinct clinical features.

Section: Infectious DiseasesNov 14, 2025

Risk Factors and Epidemiological Trends in Severe Pediatric Invasive Group A Streptococcal Disease: Insights from the Netherlands 2015–2024

Risk Factors and Epidemiological Trends in Severe Pediatric Invasive Group A Streptococcal Disease: Insights from the Netherlands 2015–2024

A comprehensive study identifies key clinical and temporal risk factors associated with severe invasive group A streptococcal disease in children, highlighting increased severity and incidence post-COVID-19 pandemic in the Netherlands.

Section: Critical CareOct 28, 2025

Common Infectious Diseases in Summer and Their Prevention

Common Infectious Diseases in Summer and Their Prevention

An overview of common infectious diseases during summer, their symptoms, transmission, and preventive measures to protect public health.

Section: Infectious DiseasesOct 1, 2025