IL-33

Unveiling the Roles of Mast Cells and Endothelial Cells in IL-33/ST2 Pathway Dysregulation in COPD Lungs

This study elucidates distinct cellular expression patterns of IL-33 and its receptor variants ST2L and sST2 in COPD lungs, highlighting mast cells and endothelial cells as key mediators in the distal lung immune response.

Targeting IL-33 in COPD: Insights from the Phase 2a FRONTIER-4 Trial of Tozorakimab