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Diabetes & EndocrinologyCaloric RestrictionIGF-1

Weight Regain Can Reverse the Metabolic Benefits of Caloric Restriction: Insights From CALERIE-2

By MedXY|May 13, 2026

CALERIE-2 post hoc analysis found that weight regain after caloric restriction can reverse improvements in insulin and IGF-1 signaling, while sustained weight loss preserves metabolic benefits and may lower biological aging markers.

Optimizing Metabolic and Physical Health in Obese Older Adults: Impact of Exercise Modalities on Insulin Secretion, CNTF, and IGF-1 During Weight Loss

Clinical UpdatesCNTFIGF-1

IGF-1

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Weight Regain Can Reverse the Metabolic Benefits of Caloric Restriction: Insights From CALERIE-2

Optimizing Metabolic and Physical Health in Obese Older Adults: Impact of Exercise Modalities on Insulin Secretion, CNTF, and IGF-1 During Weight Loss

Synergistic Effects of Combined Aerobic and Resistance Exercise with Diet on Insulin Secretion and Neurotrophic Factors in Older Adults with Obesity