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Extended HLA Haplotypes Linked to Survival After Hematopoietic Cell Transplantation

A study of 2,577 haploidentical transplants shows that extended HLA haplotypes, including a class III SNP, significantly influence mortality and relapse, potentially improving donor selection.

Jul 27, 2026

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Whole‑Genome Sequencing Reveals HLA, FCGR2B and Complement C4 Copy‑Number as Distinct Genetic Drivers of IgG4‑Related Disease in Japan

A Japanese whole‑genome sequencing study identifies FCGR2B, specific HLA amino‑acid residues, and complement C4 copy‑number variation as independent genetic risk factors for IgG4‑related disease, with PTCH1 and a lncRNA linked to Mikulicz’s

Nov 25, 2025