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Extended HLA Haplotypes Linked to Survival After Hematopoietic Cell Transplantation
Hematology-OncologyHLAhematopoietic cell transplantation

Extended HLA Haplotypes Linked to Survival After Hematopoietic Cell Transplantation

By MedXY|Jul 27, 2026

A study of 2,577 haploidentical transplants shows that extended HLA haplotypes, including a class III SNP, significantly influence mortality and relapse, potentially improving donor selection.

Whole‑Genome Sequencing Reveals HLA, FCGR2B and Complement C4 Copy‑Number as Distinct Genetic Drivers of IgG4‑Related Disease in Japan
newsHLAwhole-genome sequencing

Whole‑Genome Sequencing Reveals HLA, FCGR2B and Complement C4 Copy‑Number as Distinct Genetic Drivers of IgG4‑Related Disease in Japan

By MedXY|Nov 25, 2025

A Japanese whole‑genome sequencing study identifies FCGR2B, specific HLA amino‑acid residues, and complement C4 copy‑number variation as independent genetic risk factors for IgG4‑related disease, with PTCH1 and a lncRNA linked to Mikulicz’s

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