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Diabetes & Endocrinology

Genetic Insights into Glycemic Response: Role of SLC2A2 Variants in Sulfonylurea Efficacy from the GRADE Trial

This article explores how common genetic variants near SLC2A2 affect glycemic response to glimepiride in type 2 diabetes, highlighting potential for precision medicine in second-line diabetes therapy.

Nov 12, 2026
Diabetes & Endocrinology

Empagliflozin, Pioglitazone or Glimepiride as Third Agents with Metformin + DPP‑4 Inhibitor: Similar HbA1c Drops but Different Trade‑offs

A 24‑week randomized phase 4 trial found comparable HbA1c reductions when adding empagliflozin, pioglitazone or glimepiride to metformin plus a DPP‑4 inhibitor; metabolic and safety profiles differed, arguing for individualized third‑line s

Nov 17, 2025Sign in to read

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