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Targeting SMPD1-Driven Sphingolipid Metabolism to Disrupt KRAS Signaling in Pancreatic Ductal Adenocarcinoma

GastroenterologygastroenterologyKRAS

Targeting SMPD1-Driven Sphingolipid Metabolism to Disrupt KRAS Signaling in Pancreatic Ductal Adenocarcinoma

By MedXY|Jul 8, 2026

This study reveals that dysregulated sphingolipid metabolism via SMPD1 supports KRAS-driven pancreatic cancer progression, identifying SMPD1 as a promising therapeutic target in pancreatic ductal adenocarcinoma.

Urgent versus early ERCP in mild-to-moderate acute cholangitis: what the trial found

Gastroenterologyacute cholangitis

biliary drainage

Urgent versus early ERCP in mild-to-moderate acute cholangitis: what the trial found

By MedXY|May 28, 2026

In mild-to-moderate acute cholangitis, ERCP within 24 hours did not improve mortality or organ-failure outcomes versus ERCP within 24–48 hours, and it was linked to more procedure-related adverse events.

Reduced Intestinal Epithelial GPX4 Expression Predicts Postoperative Crohn’s Disease Recurrence and Offers a Novel Therapeutic Target

GastroenterologyCrohn’s diseasegastroenterology

Reduced Intestinal Epithelial GPX4 Expression Predicts Postoperative Crohn’s Disease Recurrence and Offers a Novel Therapeutic Target

By MedXY|Mar 22, 2026

A breakthrough study identifies epithelial Glutathione peroxidase 4 (GPX4) deficiency as a potent predictor of Crohn’s disease recurrence after surgery. The research links this biomarker to endoplasmic reticulum stress and highlights

Intestinal Ultrasound Scan in Acute Severe Ulcerative Colitis in Children: A Multicenter Clinical Study Report

GastroenterologyClinical Studygastroenterology

Intestinal Ultrasound Scan in Acute Severe Ulcerative Colitis in Children: A Multicenter Clinical Study Report

By MedXY|Mar 20, 2026

This report examines the role of Intestinal Ultrasound (IUS) in pediatric Acute Severe Ulcerative Colitis (ASUC). Results from 60 patients show that IUS metrics, specifically colonic wall thickness and the Milan Ultrasound Score, can accura

Evolution of Acute Upper GI Bleeding Management: Lessons from the 2022 UK National Audit

Emergency MedicineAUGIBclinical guidelines

Evolution of Acute Upper GI Bleeding Management: Lessons from the 2022 UK National Audit

By MedXY|Mar 15, 2026

This article examines the 2022 UK audit of acute upper gastrointestinal bleeding, highlighting improved mortality rates despite an aging, more complex patient population, while emphasizing the urgent need for restrictive transfusion practic

Rethinking the Urgency of Post-FIT Colonoscopy: Why Compliance May Take Precedence Over Speed

GastroenterologyColonoscopy Timingcolorectal cancer

Rethinking the Urgency of Post-FIT Colonoscopy: Why Compliance May Take Precedence Over Speed

By MedXY|Mar 12, 2026

A nationwide French cohort study of over 370,000 individuals reveals that delaying colonoscopy for up to 24 months after a positive FIT result does not significantly increase the risk of advanced-stage colorectal cancer, though high fecal h

New Consensus on APC Mosaicism: Transforming the Diagnosis and Management of Unexplained Polyposis

GastroenterologyAPC genecolorectal cancer

New Consensus on APC Mosaicism: Transforming the Diagnosis and Management of Unexplained Polyposis

By MedXY|Mar 9, 2026

A landmark study in Gastroenterology reveals that APC mosaicism accounts for nearly 10% of unexplained colorectal polyposis. New guidelines recommend specific testing thresholds and surveillance strategies to prevent colorectal cancer in th

Metopimazine Mesylate (NG101) for Gastroparesis: Evaluating the Gap Between Patient Global Impression and Symptom Severity Scores

Gastroenterologyclinical trialsgastroenterology

Metopimazine Mesylate (NG101) for Gastroparesis: Evaluating the Gap Between Patient Global Impression and Symptom Severity Scores

By MedXY|Feb 4, 2026

A Phase 2 trial of NG101 for gastroparesis missed its primary endpoint for nausea severity on the DIGS-DD scale but demonstrated significant improvements in Patient Global Impression of Change (PGIC) and a favorable safety profile, particul

A Glimmer of Hope for the ‘Slow Stomach’: Exploring the New Frontier in Gastroparesis Treatment

Gastroenterologyclinical trialsgastroenterology

A Glimmer of Hope for the ‘Slow Stomach’: Exploring the New Frontier in Gastroparesis Treatment

By MedXY|Feb 3, 2026

This article examines the Phase 2 trial of NG101 (metopimazine), a novel treatment for gastroparesis. While the primary endpoint was missed, significant improvements in patient-reported outcomes and a strong safety profile suggest a potenti

Can a Peripheral Opioid Antagonist Break the Cycle of Recurrent Acute Pancreatitis? Insights from the PAMORA-RAP Trial

GastroenterologygastroenterologyNaldemedine

Can a Peripheral Opioid Antagonist Break the Cycle of Recurrent Acute Pancreatitis? Insights from the PAMORA-RAP Trial

By MedXY|Feb 2, 2026

The PAMORA-RAP trial suggests that naldemedine, a peripherally acting μ-opioid receptor antagonist, may reduce the risk of recurrent acute pancreatitis by nearly 50%, offering a potential first-in-class pharmacological strategy for this hig

Mediterranean Diet Outperforms Traditional Dietary Advice for Irritable Bowel Syndrome: A Landmark Randomized Trial

GastroenterologyClinical Nutritiongastroenterology

Mediterranean Diet Outperforms Traditional Dietary Advice for Irritable Bowel Syndrome: A Landmark Randomized Trial

By MedXY|Jan 20, 2026

A randomized clinical trial published in the Annals of Internal Medicine reveals that the Mediterranean diet is superior to traditional dietary advice for managing IBS symptoms, offering a nutrient-dense, sustainable first-line intervention

Is 2 Liters of PEG Necessary? Simplified Water Prep Proves Effective for Crohn’s Capsule Endoscopy

GastroenterologyBowel PreparationCapsule Endoscopy

Is 2 Liters of PEG Necessary? Simplified Water Prep Proves Effective for Crohn’s Capsule Endoscopy

By MedXY|Jan 20, 2026

A randomized trial demonstrates that a simplified bowel preparation using clear liquids and water offers comparable diagnostic yield and cleanliness to PEG-based regimens for Crohn’s disease capsule endoscopy, while significantly improving

Rifaximin Demonstrates Superior Adherence and Faster Symptom Relief Compared to Low FODMAP Diet in Irritable Bowel Syndrome

Family Medicine & NutritiongastroenterologyIrritable Bowel Syndrome

Rifaximin Demonstrates Superior Adherence and Faster Symptom Relief Compared to Low FODMAP Diet in Irritable Bowel Syndrome

By MedXY|Jan 20, 2026

Clinical trials reveal that Rifaximin provides faster symptom relief and significantly better adherence than the low FODMAP diet in IBS patients, while also potentially restoring lactase activity in those with small intestinal bacterial ove

Unlocking the Sleeper Effect: Can Mechanism-Based Psychological Interventions Transform IBS and UC Outcomes?

GastroenterologygastroenterologyIBS

Unlocking the Sleeper Effect: Can Mechanism-Based Psychological Interventions Transform IBS and UC Outcomes?

By MedXY|Dec 29, 2025

The SOMA.GUT-RCT investigated a targeted psychological intervention for IBS and UC. While the primary 3-month endpoint showed no significant symptom reduction compared to standard care, exploratory data revealed significant psychological im

Optimized Bismuth Quadruple Therapy Surpasses Standard Triple Therapy for First-Line H. pylori Eradication

Gastroenterologyantimicrobial resistanceBismuth Quadruple Therapy

Optimized Bismuth Quadruple Therapy Surpasses Standard Triple Therapy for First-Line H. pylori Eradication

By MedXY|Dec 19, 2025

A double-blind RCT in Chile demonstrates that a 14-day optimized bismuth quadruple therapy achieves a 95% eradication rate for Helicobacter pylori, significantly outperforming standard triple therapy without increasing the burden of adverse

Probiotics Cut Clostridioides difficile Risk in Antibiotic-Exposed Patients — Small Benefit, Low Certainty

Gastroenterologyantibiotic-associated diarrheaClostridioides difficile

Probiotics Cut Clostridioides difficile Risk in Antibiotic-Exposed Patients — Small Benefit, Low Certainty

By MedXY|Dec 18, 2025

A 2025 Cochrane update finds probiotics may halve the relative risk of C. difficile-associated diarrhea in antibiotic-treated patients (ARR 1.6%, NNT 65) but evidence is low certainty and applicability varies with baseline risk.

Higher Ultraprocessed Food Intake Linked to Increased Risk of Early‑Onset Colorectal Adenomas in Women

Gastroenterologyadenomaearly-onset colorectal cancer

Higher Ultraprocessed Food Intake Linked to Increased Risk of Early‑Onset Colorectal Adenomas in Women

By MedXY|Nov 13, 2025

In a prospective analysis of 29,105 women from the Nurses’ Health Study II, greater consumption of ultraprocessed foods was associated with a 45% higher odds of early‑onset conventional colorectal adenomas, independent of obesity and

Does AI Make Endoscopists Lazy? New Multicentre Data Show Reduced Adenoma Detection After AI Exposure

AIAdenoma Detection Rateartificial intelligence

Does AI Make Endoscopists Lazy? New Multicentre Data Show Reduced Adenoma Detection After AI Exposure

By MedXY|Nov 9, 2025

A multicentre observational study reports a 6% absolute fall in adenoma detection rate for non‑AI colonoscopies after clinicians were exposed to AI-assisted polyp detection—raising concerns about endoscopist deskilling and the need for safe

Location Alone Shouldn’t Drive ESD: French Registry Finds Similar Submucosal Cancer Rates in Large Rectal and Colonic Non‑Pedunculated Polyps

GastroenterologyColorectal neoplasiaendoscopy

Location Alone Shouldn’t Drive ESD: French Registry Finds Similar Submucosal Cancer Rates in Large Rectal and Colonic Non‑Pedunculated Polyps

By MedXY|Nov 7, 2025

A multicentre French ESD registry found that, after adjusting for size and morphology, large non‑pedunculated rectal polyps do not have higher rates of submucosal invasive cancer than equivalent colonic lesions; technical outcomes of ESD we

Top U.S. Hospitals for Gastroenterology and GI Surgery: 2025-2026 Rankings and Clinical Implications

Gastroenterologyclinical outcomesgastroenterology

Top U.S. Hospitals for Gastroenterology and GI Surgery: 2025-2026 Rankings and Clinical Implications

By MedXY|Sep 30, 2025

Mayo Clinic leads U.S. News’ 2025-2026 rankings for gastroenterology and GI surgery, reflecting excellence in outcomes, capabilities, and research. This review examines the clinical context, ranking methodology, and relevance for clin

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Retatrutide in Type 2 Diabetes and MASLD: Integrative Evidence on Body Composition and Liver Fat Reduction

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