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A large population study shows frailty is independently linked to worse 1‑year outcomes after AMI across ages, with the largest relative impact in patients under 55 — underscoring the need to assess frailty beyond geriatric populations.
Large trial and real‑world data show fixed‑duration venetoclax‑obinutuzumab delivers high response and durable PFS in fit and unfit CLL patients; maintaining adequate venetoclax dose intensity appears important for MRD and long‑term outcome
The Hospital Frailty Risk Score (HFRS) predicts length of stay, mortality, and costs across all adult age groups in England, with stronger effects in older adults, supporting broader clinical use beyond the elderly.
A large-scale analysis reveals high frailty prevalence among people experiencing homelessness in England, highlighting critical socioeconomic factors influencing vulnerability.
The IFM2017-03 phase 3 trial demonstrates that a dexamethasone-sparing regimen combining daratumumab with lenalidomide markedly improves progression-free survival in frail elderly multiple myeloma patients, without increasing serious advers
This analysis of the FINEARTS-HF trial reveals that finerenone reduces cardiovascular death and heart failure worsening regardless of frailty status, without increasing adverse events, supporting its use in frail patients with HFmrEF or HFp
The RETREAT-FRAIL trial found no survival benefit from progressively reducing antihypertensive medications in frail nursing home residents aged ≥80 with controlled blood pressure, supporting individualized treatment strategies.
A 12-week anti-inflammatory dietary education significantly improved frailty, nutritional status, inflammatory biomarkers, and quality of life in frail colorectal cancer patients undergoing chemotherapy.
Switching frail, elderly atrial fibrillation patients from warfarin to standard-dose DOAC reduced stroke, fatal and intracranial bleeding, and death, though gastrointestinal bleeding increased. Major bleeding and net clinical outcome remain
This 10-year study from England details delirium’s prevalence, associated factors like dementia and frailty, and its lasting impact on mortality and care needs in acute general medicine patients, supporting targeted screening and inte
Frailty in older hospitalized adults is strongly linked to discharge to post-acute care, increased 90-day readmission rates, and higher mortality, highlighting the need for targeted discharge planning using automated frailty assessments.
