Fibroblast metabolism

WISP1 as a Therapeutic Target in Crohn’s Disease: Linking Metabolic Reprogramming to Intestinal Fibrosis

This study reveals the pivotal role of WISP1 in driving intestinal fibrosis in Crohn’s disease through fibroblast metabolic shifts and cytoskeletal remodeling, suggesting WISP1 neutralization as a novel antifibrotic intervention.