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Oncology

Derazantinib in FGFR2-Altered Intrahepatic Cholangiocarcinoma: Promising Phase 2 Efficacy with Manageable Toxicity

A pivotal Phase 2 study demonstrates that derazantinib yields meaningful responses and progression-free survival in FGFR2-aberrant advanced intrahepatic cholangiocarcinoma, with an acceptable safety profile, supporting its role as a targete

Nov 4, 2026
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Beyond Simple Inhibition: How Inavolisib Co-opts FGFR2 to Eradicate PIK3CA-Mutated Tumors

A Phase 1 study and preclinical analysis reveal that inavolisib, a PI3Kα inhibitor and degrader, leverages FGFR2 signaling to enhance the degradation of mutated p110α, yielding superior clinical benefits in PIK3CA-mutated solid tumors.

Jan 20, 2026Sign in to read

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