Hematology-Oncologyacute myeloid leukemiaepigenetic repression
Unraveling the Blockade: How Mutant IDH1 Impairs Neutrophil Differentiation in Preleukemic Hematopoiesis
By MedXY|Aug 17, 2026
Mutant IDH1 in acute myeloid leukemia causes a reversible block in neutrophil differentiation by repressing myeloid progenitor transcriptional programs, highlighting a preleukemic defect with therapeutic implications.