EGFR-mutant lung adenocarcinoma

Hypoxic Microenvironment Triggers Early Aggressive Progression in EGFR-Mutant Lung Adenocarcinoma

This study reveals that hypoxia in centrally located EGFR-mutant lung adenocarcinomas drives an alveolar lineage imbalance via the ZAKα-MAPK-c-Fos pathway, promoting early tumorigenesis. Therapeutic oxygenation can restore lineage balance a