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Central obesity in women and high overall body fat in men are linked to increased odds of dry eye disease, with distinct metabolic pathways implicated, based on a retrospective analysis of over 480,000 UK Biobank participants.
Chronic pain conditions significantly elevate the risk of developing dry eye disease, including cases requiring prescription therapy, emphasizing the need for integrated clinical assessment and management.
A 2026 Ophthalmology report identified a pain-predominant dry eye phenotype in 6.9% of patients, marked by high symptom burden, minimal surface signs, and enrichment for migraine and psychiatric comorbidity.
Alcon introduces Tryptyr, the first TRPM8 agonist eye drop, promising rapid tear production for dry eye disease. FDA-approved in May 2024 following robust phase 3 trials.