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Levothyroxine Dosing and the Risk of Suboptimal Thyroid Control: Insights from a Large Real-World Longitudinal Study
Diabetes & Endocrinologydose-responseHypothyroidism

Levothyroxine Dosing and the Risk of Suboptimal Thyroid Control: Insights from a Large Real-World Longitudinal Study

By MedXY|Jul 3, 2026

This real-world study demonstrates a dose-dependent increase in suboptimal thyroid hormone control among adults treated with levothyroxine, emphasizing the need for enhanced TSH monitoring in patients on higher doses.

How Much Aerobic Exercise Is Enough to Reduce Depression in Patients with Chronic Illness? A Dose–Response Meta-analysis Points to an Achievable Target
Internal Medicineaerobic exercise
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chronic illness

How Much Aerobic Exercise Is Enough to Reduce Depression in Patients with Chronic Illness? A Dose–Response Meta-analysis Points to an Achievable Target

By MedXY|Nov 8, 2025

A meta-analysis of 36 RCTs (n=2,500) found aerobic exercise significantly reduces depressive symptoms in people with chronic illness (Hedges’ g -0.73). A weekly dose of ≈405 MET‑min (≈120–135 min of moderate aerobic activity) reaches

Decoding the Optimal Aerobic Exercise Dose for Alleviating Depression in Youth: Evidence from a Meta-Analysis
newsadolescentschildren

Decoding the Optimal Aerobic Exercise Dose for Alleviating Depression in Youth: Evidence from a Meta-Analysis

By MedXY|Oct 12, 2025

Aerobic exercise significantly alleviates depressive symptoms in children and adolescents, especially in diagnosed adolescents, with 590 METs-min/week at moderate intensity identified as the optimal dose.

How Evening Exercise Timing and Intensity Impact Sleep Quality: Insights from a Large-Scale Biometric Study
Clinical Updatesautonomic functiondose-response

How Evening Exercise Timing and Intensity Impact Sleep Quality: Insights from a Large-Scale Biometric Study

By MedXY|Oct 6, 2025

This large cohort study reveals that late and strenuous evening exercise delays sleep onset, shortens sleep duration, lowers sleep quality, and alters autonomic function. Exercising at least 4 hours before sleep or opting for lighter intens

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