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Early Detection of Cerebral Small Vessel Disease: Diffusion MRI Reveals a Decade-Long Preclinical Phase Before White Matter Hyperintensities
Neurologycerebral small vessel diseasediffusion MRI

Early Detection of Cerebral Small Vessel Disease: Diffusion MRI Reveals a Decade-Long Preclinical Phase Before White Matter Hyperintensities

By MedXY|Sep 8, 2026

Diffusion MRI detects microstructural brain changes up to 16 years before white matter hyperintensities appear, offering a valuable early window for cerebral small vessel disease intervention and improved risk stratification.

Free Water Collapse in Limbic White Matter Predicts Memory Decline in Aging and Alzheimer Disease
NeurologyAlzheimer disease
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diffusion MRI

Free Water Collapse in Limbic White Matter Predicts Memory Decline in Aging and Alzheimer Disease

By MedXY|Dec 10, 2025

A large multisite analysis (n=4,467) finds white matter free water (FW), especially in limbic tracts (cingulum, fornix), strongly associates with cross-sectional cognition and longitudinal decline; FW interacts with amyloid, APOE ε4, and gr

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