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Early Detection of Cerebral Small Vessel Disease: Diffusion MRI Reveals a Decade-Long Preclinical Phase Before White Matter Hyperintensities

Diffusion MRI detects microstructural brain changes up to 16 years before white matter hyperintensities appear, offering a valuable early window for cerebral small vessel disease intervention and improved risk stratification.

Sep 8, 2026
Neurology

Free Water Collapse in Limbic White Matter Predicts Memory Decline in Aging and Alzheimer Disease

A large multisite analysis (n=4,467) finds white matter free water (FW), especially in limbic tracts (cingulum, fornix), strongly associates with cross-sectional cognition and longitudinal decline; FW interacts with amyloid, APOE ε4, and gr

Dec 9, 2025

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