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Targeting the CXCL9/CXCL10-CXCR3+ CD8+ T Cell Axis: Unraveling Anti-PD-1 Antibody-Associated Cardiotoxicity in Pressure Overload Heart Failure
CardiologyCD8+ T cellsheart failure

Targeting the CXCL9/CXCL10-CXCR3+ CD8+ T Cell Axis: Unraveling Anti-PD-1 Antibody-Associated Cardiotoxicity in Pressure Overload Heart Failure

By MedXY|Sep 6, 2026

Anti-PD-1 antibody exacerbates pressure overload-induced heart failure by promoting CXCR3+ CD8+ T cell infiltration, which impairs cardiomyocyte mitochondrial function via granzyme B and perforin. This study identifies a novel immunopathoge

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