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CSF biomarkers

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Neurology

CSF Biomarkers as Indicators of Disease Severity in Probable Cerebral Amyloid Angiopathy: Insights Beyond MRI

This study demonstrates that cerebrospinal fluid beta-amyloid peptides correlate with MRI markers of disease severity in probable cerebral amyloid angiopathy, suggesting CSF biomarkers provide a direct measure of vascular amyloid burden, in

Sep 6, 2026Sign in to read
Neurology

Higher Amyloid PET Signal and Lower APOE ε4 Frequency Distinguish Iatrogenic From Sporadic Cerebral Amyloid Angiopathy

A single-center cross-sectional study found that iatrogenic cerebral amyloid angiopathy carries a higher amyloid PET burden, weaker CSF-PET coupling, and less APOE ε4 enrichment than sporadic disease, supporting a biologically distinct mech

May 7, 2026Sign in to read
Clinical Updates

Differential Pathophysiological Roles of Centrum Semiovale Perivascular Spaces in Cerebral Amyloid Angiopathy and Deep Perforator Arteriopathy: A Biomarker Synthesis

This review synthesizes evidence distinguishing perivascular space enlargement mechanisms in cerebral amyloid angiopathy (CAA) versus deep perforator arteriopathy (DPA), highlighting the diagnostic utility of CSF Aβ42/40 ratios in vascular

Mar 8, 2026Sign in to read
Neurology

Advances in Alzheimer’s Diagnosis: A Comprehensive Review of CSF and Blood Biomarkers

This article reviews a systematic meta-analysis of 15 cerebrospinal fluid and blood biomarkers for Alzheimer’s disease, highlighting robust diagnostic performance of core markers T-tau, P-tau, and Aβ42 in clinical practice and researc

Oct 20, 2025Sign in to read

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