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IDH3 as a Metabolic Checkpoint Modulating Venetoclax Resistance in AML Stem Cells
Hematology-Oncologyvenetoclax resistanceCitrate Metabolism

IDH3 as a Metabolic Checkpoint Modulating Venetoclax Resistance in AML Stem Cells

By MedXY|Sep 27, 2026

This article elucidates how the TCA cycle enzyme IDH3 critically regulates metabolic fitness in AML stem cells, influencing venetoclax resistance and offering a novel target to improve therapeutic outcomes.

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