
Cardiologypulmonary arterial hypertensionCHIP genes
Impact of Germline and Somatic DNMT3A Variants on Pulmonary Arterial Hypertension: A New Frontier in Biomarkers and Therapeutics
By MedXY|Sep 8, 2026
Germline and somatic variants in DNMT3A and other CHIP genes elevate pulmonary arterial hypertension risk, including connective tissue disease-associated forms, through pro-inflammatory pathways, highlighting novel biomarkers and therapeuti