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SMOC-1, secreted by cardiomyocytes after acute myocardial infarction, supports fibrosis and scar formation, reducing cardiac rupture risk. Enhancing this pathway offers promising therapeutic potential.
This study reveals that intermittent hypoxia activates GLI1 transcription factor in cardiac fibroblasts, driving fibrosis via PKM2-mediated glycolysis, and highlights GLI1 as a promising therapeutic target in OSA-associated cardiac dysfunct
A 2026 European Heart Journal study identifies macrophage circHIPK2 as a regulator of post-MI inflammation and fibrosis, with macrophage-targeted silencing improving cardiac remodeling in mice and showing translational promise in human myoc
A 2026 European Heart Journal study identifies macrophage circHIPK2 as a regulator of post-MI inflammation and fibrosis, integrating circular RNA biology with macrophage polarization, stress-granule signaling, and emerging immune-targeted R
