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Macrophage circHIPK2 Silencing Reduces Post-Infarction Inflammation and Fibrosis and Improves Cardiac Recovery

By MedXY|Jun 10, 2026

A 2026 European Heart Journal study identifies macrophage circHIPK2 as a regulator of post-MI inflammation and fibrosis, with macrophage-targeted silencing improving cardiac remodeling in mice and showing translational promise in human myoc

Macrophage circHIPK2 After Myocardial Infarction: A New RNA Node Linking Inflammation, Stress Granules, and Fibrotic Remodelling

Clinical UpdatescircHIPK2

心脏纤维化

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Macrophage circHIPK2 Silencing Reduces Post-Infarction Inflammation and Fibrosis and Improves Cardiac Recovery

Macrophage circHIPK2 After Myocardial Infarction: A New RNA Node Linking Inflammation, Stress Granules, and Fibrotic Remodelling