GastroenterologyBIRC3Crohn’s disease
BIRC3 Gene Variants Disrupt RIPK1 Signaling, Driving Monogenic Crohn’s Disease: New Insights and Therapeutic Avenues
By MedXY|Jun 27, 2026
Rare variants in the BIRC3 gene cause defective regulation of RIPK1 signaling, leading to increased intestinal epithelial cell death and monogenic Crohn’s disease. Targeting RIPK1 offers a promising therapeutic strategy.