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Hematology-Oncologymultiple myelomaproteasome inhibitor resistance

USP8 as a Therapeutic Target in B Cell Proteostasis and Multiple Myeloma Resistance

By MedXY|Aug 12, 2026

USP8 regulates proteostasis in B cells and multiple myeloma, influencing cellular survival and response to therapy. Targeting USP8 reveals new opportunities for overcoming proteasome inhibitor resistance in multiple myeloma.

Cardiac Sarcoidosis May Be Driven by a Heart-Resident Autoimmune B-Cell Axis Linked to Periplakin

Allergy & ImmunologyB cellscardiac sarcoidosis

B cells

Latest news

USP8 as a Therapeutic Target in B Cell Proteostasis and Multiple Myeloma Resistance

Cardiac Sarcoidosis May Be Driven by a Heart-Resident Autoimmune B-Cell Axis Linked to Periplakin

Immunosuppressive Roles of Tumour-Infiltrating B Cells in Intrahepatic Cholangiocarcinoma and Implications for Chemoimmunotherapy Outcomes