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Early B-Cell Depletion Patterns Predict Long-Term Rituximab Outcomes and Refractory Disease in Rheumatoid Arthritis

High-sensitivity flow cytometry reveals that early plasmablast depletion predicts 5-year rituximab response in rheumatoid arthritis, while incomplete memory B-cell depletion signals poly-refractory disease.

Aug 20, 2026
Neurology

Comparative Effectiveness and Safety of Emerging Myasthenia Gravis Therapies: Insights From a Bayesian Network Meta-Analysis

A Bayesian network meta-analysis comparing FcRn inhibitors, C5 complement inhibitors, and CD19+ B-cell depletion therapies reveals comparable efficacy but varied safety profiles in generalized myasthenia gravis treatment, highlighting the n

Jul 20, 2026
Hematology-Oncology

Revolutionizing iTTP Treatment: Reverse CAR T Cells Target Autoreactive B Cells with Precision

A groundbreaking study introduces reverse CAR T cells to selectively deplete anti-ADAMTS13 autoreactive B cells in immune-mediated thrombotic thrombocytopenic purpura (iTTP), offering a novel, precise, and potentially safer therapeutic appr

Apr 24, 2026

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