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This article explores distinct immune cell activations in ACPA-positive individuals progressing to rheumatoid arthritis, emphasizing type I interferon activity prior to ultrasound-detectable synovitis and subsequent inflammatory shifts mark
This study reveals that genetic risk factors and immune pathways differ significantly between type 1 diabetes patients stratified by HLA-DR3 and HLA-DR4 status, providing insights into disease heterogeneity and personalized risk mechanisms.
Low-dose IL-2 immunotherapy demonstrates broad, disease-modifying effects by selectively expanding regulatory T cells (Tregs), offering a promising strategy across diverse diseases including autoimmunity, neurodegeneration, metabolic dysfun
