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The Fibrinogen αC Region Promotes Arterial Thrombosis in Hypofibrinogenemia
Cardiologycarotid artery thrombosisfibrinogen

The Fibrinogen αC Region Promotes Arterial Thrombosis in Hypofibrinogenemia

By MedXY|Jun 10, 2026

Low fibrinogen alone did not prevent arterial thrombosis in humans or mice, but loss of the fibrinogen αC region reduced clot formation. The study suggests fibrinogen structure, not just level, influences arterial thrombotic risk.

Loss of the Fibrinogen αC Region, Rather Than Hypofibrinogenemia Alone, Attenuates Experimental Arterial Thrombosis
Cardiologyfibrinogen αC regionGPVI
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Loss of the Fibrinogen αC Region, Rather Than Hypofibrinogenemia Alone, Attenuates Experimental Arterial Thrombosis

By MedXY|Jun 6, 2026

Mouse and human observational data suggest that the fibrinogen αC region is a key determinant of arterial thrombosis under hypofibrinogenemic conditions, likely through platelet GPVI-dependent mechanisms.

ALDH2 rs671 Variant and Thrombotic Risk: Unveiling a New Target for Precision Antiplatelet Therapy in East Asian Populations
CardiologyHoạt hóa Tiểu cầumyocardial infarction

ALDH2 rs671 Variant and Thrombotic Risk: Unveiling a New Target for Precision Antiplatelet Therapy in East Asian Populations

By MedXY|Mar 3, 2026

Recent research reveals that the common ALDH2 rs671 genetic variant significantly enhances platelet activation and arterial thrombosis through aldehyde accumulation, reactive oxygen species, and ACAD10-mediated mitophagy, identifying ALDH2

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