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Ensitrelvir Demonstrates Potent Antiviral Efficacy Comparable to Nirmatrelvir in Early COVID-19: Insights from the PLATCOV Trial

By MedXY|Mar 2, 2026

The PLATCOV trial identifies ensitrelvir as a highly effective oral antiviral, achieving rapid SARS-CoV-2 clearance comparable to ritonavir-boosted nirmatrelvir. This phase 2 adaptive trial suggests ensitrelvir is a viable alternative for o

Infectious DiseasesAntiviralsCOVID-19

Ensitrelvir Matches Ritonavir‑Boosted Nirmatrelvir for Rapid SARS‑CoV‑2 Clearance — PLATCOV Phase 2 Results Support an Alternative Oral Mpro Inhibitor

By MedXY|Nov 23, 2025

Phase 2 PLATCOV results show oral ensitrelvir accelerates SARS‑CoV‑2 clearance versus no drug and has antiviral effects close to ritonavir‑boosted nirmatrelvir, supporting further phase 3 evaluation.