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MedXY AI/MedXY News/Tag: antiseizure medications
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Paternal Valproate Exposure and Offspring Neurodevelopmental Outcomes: A Comprehensive Review of Current Evidence
Clinical Updatesneurodevelopmental disorderspaternal exposure

Paternal Valproate Exposure and Offspring Neurodevelopmental Outcomes: A Comprehensive Review of Current Evidence

By MedXY|Aug 24, 2026

This review synthesizes evidence on paternal valproate exposure and offspring neurodevelopmental risks, highlighting recent large cohort data that challenge prior concerns of increased neurodevelopmental disorders or congenital malformation

Balancing Risks: Safety Profiles of Antiseizure Medications in Epilepsy Patients on Direct Oral Anticoagulants
Cardiologybleeding risk
epilepsy

Balancing Risks: Safety Profiles of Antiseizure Medications in Epilepsy Patients on Direct Oral Anticoagulants

By MedXY|Aug 18, 2026

This study reveals distinct thromboembolic, bleeding, and mortality risks based on antiseizure medication selection in epilepsy patients receiving direct oral anticoagulants, highlighting the critical role of ASM choice on patient safety an

Cenobamate Outperforms Brivaracetam, Lacosamide, and Perampanel in Real-World Focal Epilepsy Management
Neurologyantiseizure medicationsCenobamate

Cenobamate Outperforms Brivaracetam, Lacosamide, and Perampanel in Real-World Focal Epilepsy Management

By MedXY|Feb 10, 2026

A large multicenter real-world study indicates that cenobamate provides superior effectiveness and seizure freedom rates compared to brivaracetam, lacosamide, and perampanel in adults with drug-resistant focal epilepsy, despite a higher inc

Seizure Burden Falls Over Time in Treatment‑Resistant Focal Epilepsy: Implications for Interpreting Open‑Label Disease‑Modifying Claims
Neurologyantiseizure medicationsLongitudinal Cohort

Seizure Burden Falls Over Time in Treatment‑Resistant Focal Epilepsy: Implications for Interpreting Open‑Label Disease‑Modifying Claims

By MedXY|Dec 7, 2025

The HEP2 prospective cohort shows that most patients with focal treatment‑resistant epilepsy experienced substantial seizure reductions over 18–36 months; ASM additions produced modest gains but rarely achieved freedom, and device-treated p

Delayed Seizure Control in Focal Epilepsy: Insights from the Human Epilepsy Project
Neurologyantiseizure medicationsfocal epilepsy

Delayed Seizure Control in Focal Epilepsy: Insights from the Human Epilepsy Project

By MedXY|Oct 5, 2025

New data reveal many patients with focal epilepsy experience seizures beyond the first treatment year, with nearly a quarter developing resistance to antiseizure medications, underscoring the need for optimized treatment strategies.

Evolving Patterns in Antiseizure Drug Use During Pregnancy: Safer Choices and New Uncertainties
Clinical Updatesantiseizure medicationsdrug safety

Evolving Patterns in Antiseizure Drug Use During Pregnancy: Safer Choices and New Uncertainties

By MedXY|Sep 30, 2025

A decade-long French study reveals declining prenatal exposure to high-risk antiseizure drugs, increased use of safer alternatives, and a notable rise in prescriptions for newer drugs with uncertain safety profiles.

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