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Longitudinal Changes in Cortisol Secretion and Cardiometabolic Outcomes in Benign Adrenal Incidentalomas: Insights from a Large Retrospective Cohort
Diabetes & Endocrinologyadrenal incidentalomacardiometabolic risk

Longitudinal Changes in Cortisol Secretion and Cardiometabolic Outcomes in Benign Adrenal Incidentalomas: Insights from a Large Retrospective Cohort

By MedXY|Jul 10, 2026

This study examines how temporal cortisol secretion changes in benign adrenal incidentalomas relate to long-term cardiometabolic outcomes and mortality, highlighting the significance of persistent mild autonomous cortisol secretion for hype

Most Bilateral Adrenal Lesions Are Benign and Concordant, but Asynchronous Presentation Signals Higher Malignancy Risk
Diabetes & Endocrinology
adrenal incidentaloma
adrenal malignancy

Most Bilateral Adrenal Lesions Are Benign and Concordant, but Asynchronous Presentation Signals Higher Malignancy Risk

By MedXY|May 13, 2026

A large retrospective cohort shows that bilateral adrenal masses are usually benign and concordant, but asynchronous or discordant lesions identify a clinically important subgroup enriched for malignancy and pheochromocytoma.

Adrenalectomy for Mild Autonomous Cortisol Secretion Was Linked to Lower Mortality, but the Survival Signal Requires Cautious Interpretation
Diabetes & Endocrinologyadrenal incidentalomaadrenalectomy

Adrenalectomy for Mild Autonomous Cortisol Secretion Was Linked to Lower Mortality, but the Survival Signal Requires Cautious Interpretation

By MedXY|May 11, 2026

In a multi-institutional retrospective cohort, adrenalectomy for mild autonomous cortisol secretion was associated with lower mortality and less new-onset diabetes than nonoperative care, although sensitivity analysis weakened the survival

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